searching ... STRING: functional protein association networks

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organism

protein

Drosophila melanogaster

gkt - Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] [a.k.a. FBgn0260817, gkt-PA, FBpp0077263]

Caenorhabditis elegans

F52C12.1 - Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] [a.k.a. F52C12.1a, Tdpo-1, CDH93126]

Escherichia coli K12

pflD - Putative glycine radical domain-containing pyruvate formate-lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family. [a.k.a. b3951, AAC76933.1, yijL]

Escherichia coli K12

ybiW - Putative pyruvate formate lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family. [a.k.a. AAC73910.1, b0823, WP_000209309.1]

Pseudomonas aeruginosa

queE - Probable radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. [a.k.a. PA0975, AAG04364.1, EC 4.3.99.3, probable radical activating enzyme, Probable radical activating enzyme, ...]

Pseudomonas aeruginosa

PA2726 - Probable radical activating enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). [a.k.a. AAG06114.1, NP_251416.1, probable radical activating enzyme, Probable radical activating enzyme]

Psychrobacter arcticus

queE - Probable radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. [a.k.a. Psyc_0736, AAZ18590.1, EC 4.3.99.3, probable radical activating enzyme, Probable radical activating enzyme, ...]

Streptomyces clavuligerus

ANW19125.1 - Radical activating enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. [a.k.a. BB341_13300, E2PXN9, SCLAV_3058, Probable radical activating enzyme]

gamma proteobacterium HTCC2143

queE - Probable radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. [a.k.a. GP2143_02909, EAW30839.1, A0YEK3_9GAMM, probable radical activating enzyme, Probable radical activating enzyme, ...]

10)

Ralstonia solanacearum

queE - Probable organic radical activating enzyme protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. [a.k.a. RSc1449, CAD15151.1, EC 4.3.99.3]

11)

Idiomarina loihiensis

IL0187 - Radical enzyme activating protein; Probably involved in ribonucleoside-triphosphate reductase activation. [a.k.a. AAV81030.1, WP_011233450.1, Radical enzyme activating protein]

12)

Burkholderia pseudomallei

BPSL2358 - Weakly similar to Clostridium pasteurianum pyruvate formate-lyase activating enzyme Act SWALL:PFLA_CLOPA (SWALL:Q46267) (238 aa) fasta scores: E(): 1e-05, 27.75% id in 209 aa. Similar to Pseudomonas aeruginosa probable radical-activating enzyme pa1919 SWALL:Q9I2I5 (EMBL:AE004618) (232 aa) fasta scores: E(): 3.2e-37, 50.21% id in 231 aa. [a.k.a. CAH36360.1, 3092097, IPR012840]

13)

Wolinella succinogenes

WS0687 - PROBABLE RADICAL-ACTIVATING ENZYME. [a.k.a. CAE09813.1, IPR012840, PUTATIVE RADICAL-ACTIVATING ENZYME]

14)

Prevotella multisaccharivorax

EGN57644.1 - COGs: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); InterPro IPR007197; KEGG: bfr:BF3170 anaerobic sulfatase-maturase; PFAM: Radical SAM; SPTR: Probable arylsulfatase-activating protein AslB; IMG reference gene:2503876324; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic sulfatase-maturating enzyme; radical SAM additional 4Fe4S-binding domain. [a.k.a. Premu_2258, F8N8P9, WP_007575349.1]

15)

Bacillus subtilis 168

yydG - Putative AdoMet radical enzyme; Required for production of the modified peptide YydF (Probable). May activate a metalloenzyme (Potential). [a.k.a. BSU40170, CAB16054.1, YYDG_BACSU]

16)

Clostridium perfringens 13

CPE0635 - Probable arylsulfatase activating enzyme; Involved in 'Cys-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of cysteine into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM) (By similarity). [a.k.a. BAB80341.1, gene:10489896, NC_003366.1]

17)

Azoarcus sp. BH72

icmF - Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. [a.k.a. azo0696, CAL93313.1, WP_011764431.1]

18)

Schizosaccharomyces pombe

tdp1 - Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] [a.k.a. Tdp1, EC 3.1.4.-, 2539579]

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